2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Louisville | 8 | 7 | 39 | 46 | 5.75 |
| 2 | North Carolina | 9 | 9 | 36 | 45 | 5.00 |
| 3 | Clemson | 8 | 5 | 35 | 40 | 5.00 |
| 4 | Virginia Tech | 8 | 6 | 34 | 40 | 5.00 |
| 5 | North Carolina State | 8 | 9 | 33 | 42 | 5.25 |
| 6 | Virginia | 8 | 6 | 31 | 37 | 4.63 |
| 6 | Duke | 8 | 3 | 31 | 34 | 4.25 |
| 8 | Pittsburgh | 9 | 13 | 29 | 42 | 4.67 |
| 9 | Florida State | 8 | 8 | 28 | 36 | 4.50 |
| 10 | Wake Forest | 10 | 9 | 27 | 36 | 3.60 |
| 11 | Boston College | 8 | 4 | 23 | 27 | 3.38 |
| 12 | Syracuse | 8 | 3 | 22 | 25 | 3.13 |
| 13 | Miami (Florida) | 8 | 6 | 19 | 25 | 3.13 |
| 14 | Georgia Tech | 8 | 1 | 18 | 19 | 2.38 |