2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 11 | 9 | 47 | 56 | 5.09 |
| 2 | Louisville | 10 | 7 | 42 | 49 | 4.90 |
| 3 | Duke | 10 | 8 | 38 | 46 | 4.60 |
| 3 | Virginia | 9 | 7 | 38 | 45 | 5.00 |
| 5 | North Carolina | 10 | 9 | 37 | 46 | 4.60 |
| 6 | North Carolina State | 9 | 9 | 36 | 45 | 5.00 |
| 6 | Virginia Tech | 10 | 7 | 36 | 43 | 4.30 |
| 8 | Pittsburgh | 11 | 15 | 34 | 49 | 4.45 |
| 9 | Wake Forest | 11 | 11 | 30 | 41 | 3.73 |
| 10 | Florida State | 9 | 11 | 29 | 40 | 4.44 |
| 11 | Boston College | 9 | 6 | 26 | 32 | 3.56 |
| 12 | Miami (Florida) | 10 | 6 | 22 | 28 | 2.80 |
| 12 | Syracuse | 9 | 3 | 22 | 25 | 2.78 |
| 14 | Georgia Tech | 9 | 1 | 19 | 20 | 2.22 |