2021 Atlantic Coast Conference Leaders Passes Defended - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 7 | 5 | 28 | 33 | 4.71 |
| 2 | Louisville | 6 | 3 | 24 | 27 | 4.50 |
| 3 | Duke | 5 | 1 | 22 | 23 | 4.60 |
| 4 | North Carolina State | 5 | 5 | 21 | 26 | 5.20 |
| 4 | Virginia | 5 | 3 | 21 | 24 | 4.80 |
| 6 | Pittsburgh | 7 | 10 | 20 | 30 | 4.29 |
| 6 | North Carolina | 6 | 2 | 20 | 22 | 3.67 |
| 8 | Wake Forest | 8 | 7 | 19 | 26 | 3.25 |
| 9 | Virginia Tech | 6 | 4 | 16 | 20 | 3.33 |
| 10 | Georgia Tech | 6 | 1 | 15 | 16 | 2.67 |
| 11 | Florida State | 5 | 7 | 13 | 20 | 4.00 |
| 11 | Boston College | 6 | 5 | 13 | 18 | 3.00 |
| 11 | Syracuse | 5 | 2 | 13 | 15 | 3.00 |
| 14 | Miami (Florida) | 5 | 4 | 7 | 11 | 2.20 |