2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 12 | 11 | 50 | 61 | 5.08 |
| 2 | Virginia | 11 | 8 | 47 | 55 | 5.00 |
| 3 | Louisville | 12 | 8 | 44 | 52 | 4.33 |
| 4 | North Carolina State | 11 | 14 | 43 | 57 | 5.18 |
| 5 | Pittsburgh | 13 | 15 | 42 | 57 | 4.38 |
| 5 | Virginia Tech | 12 | 10 | 42 | 52 | 4.33 |
| 5 | Duke | 11 | 8 | 42 | 50 | 4.55 |
| 8 | North Carolina | 12 | 10 | 40 | 50 | 4.17 |
| 9 | Wake Forest | 13 | 14 | 38 | 52 | 4.00 |
| 10 | Florida State | 11 | 14 | 34 | 48 | 4.36 |
| 11 | Boston College | 11 | 8 | 32 | 40 | 3.64 |
| 12 | Syracuse | 11 | 4 | 27 | 31 | 2.82 |
| 13 | Miami (Florida) | 11 | 7 | 26 | 33 | 3.00 |
| 14 | Georgia Tech | 11 | 1 | 22 | 23 | 2.09 |