2021 Atlantic Coast Conference Leaders Total Defense - Games vs. FCS (I-AA) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Duke | 1 | 208 | 56 | 69 | 264 | 3.83 | 264.0 |
| 2 | Pittsburgh | 1 | 100 | 60 | 53 | 160 | 3.02 | 160.0 |
| 3 | Virginia Tech | 1 | 160 | 77 | 59 | 237 | 4.02 | 237.0 |
| 4 | Boston College | 1 | 105 | 84 | 54 | 189 | 3.50 | 189.0 |
| 5 | Virginia | 1 | 94 | 89 | 53 | 183 | 3.45 | 183.0 |
| 6 | North Carolina | 1 | 209 | 93 | 55 | 302 | 5.49 | 302.0 |
| 7 | North Carolina State | 1 | 92 | 104 | 53 | 196 | 3.70 | 196.0 |
| 8 | Georgia Tech | 1 | 154 | 111 | 63 | 265 | 4.21 | 265.0 |
| 9 | Syracuse | 1 | 7 | 128 | 54 | 135 | 2.50 | 135.0 |
| 10 | Clemson | 1 | 103 | 132 | 61 | 235 | 3.85 | 235.0 |
| 11 | Louisville | 1 | 86 | 149 | 56 | 235 | 4.20 | 235.0 |
| 12 | Miami (Florida) | 1 | 29 | 169 | 63 | 198 | 3.14 | 198.0 |
| 13 | Wake Forest | 1 | 141 | 195 | 70 | 336 | 4.80 | 336.0 |
| 14 | Florida State | 1 | 108 | 242 | 77 | 350 | 4.55 | 350.0 |