2021 Louisville Cardinals Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 2037 | 3180 | 898 | 5217 | 5.81 | 401.3 |
| at Home | 7 | 1083 | 1396 | 466 | 2479 | 5.32 | 354.1 |
| on Road/Neutral Site | 6 | 954 | 1784 | 432 | 2738 | 6.34 | 456.3 |
| in Wins | 6 | 949 | 1063 | 400 | 2012 | 5.03 | 335.3 |
| in Losses | 7 | 1088 | 2117 | 498 | 3205 | 6.44 | 457.9 |
| vs. Conference | 8 | 1032 | 2058 | 577 | 3090 | 5.36 | 386.3 |
| vs. Non-Conference | 5 | 1005 | 1122 | 321 | 2127 | 6.63 | 425.4 |
| vs. Ranked (AP) | 5 | 896 | 1391 | 352 | 2287 | 6.50 | 457.4 |
| vs. Unranked (AP) | 8 | 1141 | 1789 | 546 | 2930 | 5.37 | 366.3 |
| vs. FBS (I-A) | 12 | 1951 | 3031 | 842 | 4982 | 5.92 | 415.2 |
| vs. FCS (I-AA) | 1 | 86 | 149 | 56 | 235 | 4.20 | 235.0 |
| vs. FBS Winning | 7 | 1265 | 1834 | 476 | 3099 | 6.51 | 442.7 |
| vs. FBS Non-Winning | 5 | 686 | 1197 | 366 | 1883 | 5.14 | 376.6 |
| vs. FBS Power 5 | 10 | 1582 | 2588 | 718 | 4170 | 5.81 | 417.0 |
| vs. FBS non-Power 5 | 2 | 369 | 443 | 124 | 812 | 6.55 | 406.0 |
| in August/September | 4 | 691 | 982 | 268 | 1673 | 6.24 | 418.3 |
| in October | 4 | 381 | 1269 | 298 | 1650 | 5.54 | 412.5 |
| in November | 4 | 808 | 690 | 272 | 1498 | 5.51 | 374.5 |
| in December/January | 1 | 157 | 239 | 60 | 396 | 6.60 | 396.0 |