2021 Duke Blue Devils Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 12 | 2470 | 3741 | 873 | 6211 | 7.11 | 517.6 |
| at Home | 7 | 1458 | 2045 | 512 | 3503 | 6.84 | 500.4 |
| on Road/Neutral Site | 5 | 1012 | 1696 | 361 | 2708 | 7.50 | 541.6 |
| in Wins | 3 | 572 | 639 | 212 | 1211 | 5.71 | 403.7 |
| in Losses | 9 | 1898 | 3102 | 661 | 5000 | 7.56 | 555.6 |
| vs. Conference | 8 | 1747 | 2778 | 591 | 4525 | 7.66 | 565.6 |
| vs. Non-Conference | 4 | 723 | 963 | 282 | 1686 | 5.98 | 421.5 |
| vs. Ranked (AP) | 2 | 486 | 827 | 169 | 1313 | 7.77 | 656.5 |
| vs. Unranked (AP) | 10 | 1984 | 2914 | 704 | 4898 | 6.96 | 489.8 |
| vs. FBS (I-A) | 11 | 2262 | 3685 | 804 | 5947 | 7.40 | 540.6 |
| vs. FCS (I-AA) | 1 | 208 | 56 | 69 | 264 | 3.83 | 264.0 |
| vs. FBS Winning | 3 | 626 | 1217 | 257 | 1843 | 7.17 | 614.3 |
| vs. FBS Non-Winning | 8 | 1636 | 2468 | 547 | 4104 | 7.50 | 513.0 |
| vs. FBS Power 5 | 10 | 2111 | 3361 | 734 | 5472 | 7.46 | 547.2 |
| vs. FBS non-Power 5 | 1 | 151 | 324 | 70 | 475 | 6.79 | 475.0 |
| in August/September | 4 | 723 | 963 | 282 | 1686 | 5.98 | 421.5 |
| in October | 4 | 706 | 1393 | 296 | 2099 | 7.09 | 524.8 |
| in November | 4 | 1041 | 1385 | 295 | 2426 | 8.22 | 606.5 |
| in December/January | 0 | 0 | 0 | 0 | 0 | - | - |