2021 Atlantic Coast Conference Leaders Total Defense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 321 | 676 | 231 | 997 | 4.32 | 249.3 |
| 2 | Georgia Tech | 4 | 540 | 679 | 262 | 1219 | 4.65 | 304.8 |
| 3 | Syracuse | 4 | 341 | 704 | 249 | 1045 | 4.20 | 261.3 |
| 4 | Clemson | 4 | 467 | 708 | 290 | 1175 | 4.05 | 293.8 |
| 5 | Virginia Tech | 4 | 552 | 761 | 258 | 1313 | 5.09 | 328.3 |
| 6 | Boston College | 4 | 392 | 762 | 238 | 1154 | 4.85 | 288.5 |
| 7 | Pittsburgh | 4 | 438 | 822 | 262 | 1260 | 4.81 | 315.0 |
| 8 | North Carolina | 4 | 584 | 945 | 278 | 1529 | 5.50 | 382.3 |
| 9 | Wake Forest | 4 | 477 | 955 | 284 | 1432 | 5.04 | 358.0 |
| 10 | Duke | 4 | 723 | 963 | 282 | 1686 | 5.98 | 421.5 |
| 11 | Louisville | 4 | 691 | 982 | 268 | 1673 | 6.24 | 418.3 |
| 12 | Virginia | 5 | 974 | 1090 | 336 | 2064 | 6.14 | 412.8 |
| 13 | Florida State | 4 | 529 | 1131 | 317 | 1660 | 5.24 | 415.0 |
| 14 | Miami (Florida) | 5 | 677 | 1251 | 364 | 1928 | 5.30 | 385.6 |