2021 Atlantic Coast Conference Leaders Total Defense - Games in December/January Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 66 | 204 | 60 | 270 | 4.50 | 270.0 |
| 2 | Louisville | 1 | 157 | 239 | 60 | 396 | 6.60 | 396.0 |
| 3 | North Carolina | 1 | 301 | 242 | 66 | 543 | 8.23 | 543.0 |
| 4 | Virginia Tech | 1 | 206 | 275 | 53 | 481 | 9.08 | 481.0 |
| 5 | Wake Forest | 2 | 223 | 438 | 134 | 661 | 4.93 | 330.5 |
| 6 | Pittsburgh | 2 | 138 | 567 | 171 | 705 | 4.12 | 352.5 |