2021 Pittsburgh Panthers Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 14 | 1249 | 3700 | 978 | 4949 | 5.06 | 353.5 |
| at Home | 7 | 652 | 1944 | 475 | 2596 | 5.47 | 370.9 |
| on Road/Neutral Site | 7 | 597 | 1756 | 503 | 2353 | 4.68 | 336.1 |
| in Wins | 11 | 969 | 2563 | 736 | 3532 | 4.80 | 321.1 |
| in Losses | 3 | 280 | 1137 | 242 | 1417 | 5.86 | 472.3 |
| vs. Conference | 9 | 755 | 2524 | 630 | 3279 | 5.20 | 364.3 |
| vs. Non-Conference | 5 | 494 | 1176 | 348 | 1670 | 4.80 | 334.0 |
| vs. Ranked (AP) | 3 | 302 | 718 | 233 | 1020 | 4.38 | 340.0 |
| vs. Unranked (AP) | 11 | 947 | 2982 | 745 | 3929 | 5.27 | 357.2 |
| vs. FBS (I-A) | 13 | 1149 | 3640 | 925 | 4789 | 5.18 | 368.4 |
| vs. FCS (I-AA) | 1 | 100 | 60 | 53 | 160 | 3.02 | 160.0 |
| vs. FBS Winning | 6 | 662 | 1739 | 455 | 2401 | 5.28 | 400.2 |
| vs. FBS Non-Winning | 7 | 487 | 1901 | 470 | 2388 | 5.08 | 341.1 |
| vs. FBS Power 5 | 11 | 947 | 3116 | 782 | 4063 | 5.20 | 369.4 |
| vs. FBS non-Power 5 | 2 | 202 | 524 | 143 | 726 | 5.08 | 363.0 |
| in August/September | 4 | 438 | 822 | 262 | 1260 | 4.81 | 315.0 |
| in October | 4 | 391 | 1070 | 257 | 1461 | 5.68 | 365.3 |
| in November | 4 | 282 | 1241 | 288 | 1523 | 5.29 | 380.8 |
| in December/January | 2 | 138 | 567 | 171 | 705 | 4.12 | 352.5 |