2021 Clemson Tigers Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 1252 | 2719 | 894 | 3971 | 4.44 | 305.5 |
| at Home | 6 | 324 | 1312 | 396 | 1636 | 4.13 | 272.7 |
| on Road/Neutral Site | 7 | 928 | 1407 | 498 | 2335 | 4.69 | 333.6 |
| in Wins | 10 | 821 | 2044 | 655 | 2865 | 4.37 | 286.5 |
| in Losses | 3 | 431 | 675 | 239 | 1106 | 4.63 | 368.7 |
| vs. Conference | 8 | 940 | 1965 | 592 | 2905 | 4.91 | 363.1 |
| vs. Non-Conference | 5 | 312 | 754 | 302 | 1066 | 3.53 | 213.2 |
| vs. Ranked (AP) | 4 | 467 | 1045 | 314 | 1512 | 4.82 | 378.0 |
| vs. Unranked (AP) | 9 | 785 | 1674 | 580 | 2459 | 4.24 | 273.2 |
| vs. FBS (I-A) | 12 | 1149 | 2587 | 833 | 3736 | 4.48 | 311.3 |
| vs. FCS (I-AA) | 1 | 103 | 132 | 61 | 235 | 3.85 | 235.0 |
| vs. FBS Winning | 6 | 576 | 1412 | 436 | 1988 | 4.56 | 331.3 |
| vs. FBS Non-Winning | 6 | 573 | 1175 | 397 | 1748 | 4.40 | 291.3 |
| vs. FBS Power 5 | 11 | 1170 | 2467 | 775 | 3637 | 4.69 | 330.6 |
| vs. FBS non-Power 5 | 1 | -21 | 120 | 58 | 99 | 1.71 | 99.0 |
| in August/September | 4 | 467 | 708 | 290 | 1175 | 4.05 | 293.8 |
| in October | 4 | 438 | 980 | 279 | 1418 | 5.08 | 354.5 |
| in November | 4 | 281 | 827 | 265 | 1108 | 4.18 | 277.0 |
| in December/January | 1 | 66 | 204 | 60 | 270 | 4.50 | 270.0 |