2021 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 12 | 1149 | 2587 | 833 | 3736 | 4.48 | 311.3 |
| 2 | North Carolina State | 11 | 1387 | 2387 | 751 | 3774 | 5.03 | 343.1 |
| 3 | Pittsburgh | 13 | 1149 | 3640 | 925 | 4789 | 5.18 | 368.4 |
| 4 | Florida State | 11 | 1627 | 2556 | 797 | 4183 | 5.25 | 380.3 |
| 5 | Syracuse | 11 | 1506 | 2323 | 722 | 3829 | 5.30 | 348.1 |
| 6 | Boston College | 11 | 1938 | 1998 | 706 | 3936 | 5.58 | 357.8 |
| 6 | Miami (Florida) | 11 | 1639 | 2838 | 802 | 4477 | 5.58 | 407.0 |
| 8 | Louisville | 12 | 1951 | 3031 | 842 | 4982 | 5.92 | 415.2 |
| 9 | Wake Forest | 13 | 2597 | 2854 | 918 | 5451 | 5.94 | 419.3 |
| 10 | Virginia Tech | 12 | 2038 | 2837 | 814 | 4875 | 5.99 | 406.3 |
| 11 | North Carolina | 12 | 2131 | 3001 | 834 | 5132 | 6.15 | 427.7 |
| 12 | Georgia Tech | 11 | 2030 | 3165 | 763 | 5195 | 6.81 | 472.3 |
| 13 | Virginia | 11 | 2616 | 2793 | 791 | 5409 | 6.84 | 491.7 |
| 14 | Duke | 11 | 2262 | 3685 | 804 | 5947 | 7.40 | 540.6 |