2021 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 6 | 576 | 1412 | 436 | 1988 | 4.56 | 331.3 |
| 2 | North Carolina State | 4 | 336 | 1020 | 275 | 1356 | 4.93 | 339.0 |
| 3 | Pittsburgh | 6 | 662 | 1739 | 455 | 2401 | 5.28 | 400.2 |
| 4 | Florida State | 5 | 607 | 1444 | 372 | 2051 | 5.51 | 410.2 |
| 5 | Syracuse | 5 | 581 | 1259 | 330 | 1840 | 5.58 | 368.0 |
| 6 | Boston College | 3 | 538 | 694 | 212 | 1232 | 5.81 | 410.7 |
| 7 | Virginia Tech | 5 | 714 | 1339 | 342 | 2053 | 6.00 | 410.6 |
| 8 | North Carolina | 7 | 1351 | 1817 | 514 | 3168 | 6.16 | 452.6 |
| 9 | Miami (Florida) | 5 | 646 | 1643 | 365 | 2289 | 6.27 | 457.8 |
| 10 | Louisville | 7 | 1265 | 1834 | 476 | 3099 | 6.51 | 442.7 |
| 11 | Wake Forest | 4 | 935 | 1070 | 306 | 2005 | 6.55 | 501.3 |
| 12 | Virginia | 5 | 1175 | 1336 | 367 | 2511 | 6.84 | 502.2 |
| 13 | Georgia Tech | 6 | 1098 | 1607 | 389 | 2705 | 6.95 | 450.8 |
| 14 | Duke | 3 | 626 | 1217 | 257 | 1843 | 7.17 | 614.3 |