2021 Atlantic Coast Conference Leaders Total Defense - Games Won Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 10 | 821 | 2044 | 655 | 2865 | 4.37 | 286.5 |
| 2 | Pittsburgh | 11 | 969 | 2563 | 736 | 3532 | 4.80 | 321.1 |
| 3 | Boston College | 6 | 767 | 965 | 358 | 1732 | 4.84 | 288.7 |
| 4 | Syracuse | 5 | 622 | 916 | 315 | 1538 | 4.88 | 307.6 |
| 5 | North Carolina State | 9 | 1246 | 1582 | 578 | 2828 | 4.89 | 314.2 |
| 6 | Georgia Tech | 3 | 414 | 709 | 228 | 1123 | 4.93 | 374.3 |
| 7 | Miami (Florida) | 7 | 759 | 1696 | 489 | 2455 | 5.02 | 350.7 |
| 8 | Louisville | 6 | 949 | 1063 | 400 | 2012 | 5.03 | 335.3 |
| 9 | Florida State | 5 | 793 | 946 | 337 | 1739 | 5.16 | 347.8 |
| 10 | Virginia Tech | 6 | 822 | 1317 | 401 | 2139 | 5.33 | 356.5 |
| 11 | Virginia | 6 | 992 | 1298 | 415 | 2290 | 5.52 | 381.7 |
| 12 | Wake Forest | 11 | 1963 | 2350 | 764 | 4313 | 5.65 | 392.1 |
| 12 | North Carolina | 6 | 909 | 1582 | 441 | 2491 | 5.65 | 415.2 |
| 14 | Duke | 3 | 572 | 639 | 212 | 1211 | 5.71 | 403.7 |