2021 Big 12 Conference Leaders Interceptions - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | JT Woods | Baylor | SR | S | 4 | 3 | 36 | 1 | 0.75 |
| 1 | Al Walcott | Baylor | JR | CB | 2 | 1 | 96 | 1 | 0.50 |
| 1 | Marquis Waters | Texas Tech | SR | DB | 3 | 1 | 72 | 1 | 0.33 |
| 1 | Riko Jeffers | Texas Tech | SR | LB | 4 | 1 | 13 | 1 | 0.25 |