2021 Big 12 Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Al Walcott | Baylor | JR | CB | 11 | 3 | 101 | 1 | 0.27 |
| 1 | Jacobee Bryant | Kansas | FR | CB | 9 | 2 | 31 | 1 | 0.22 |
| 1 | Jason Taylor II | Okla St | JR | S | 10 | 2 | 85 | 1 | 0.20 |
| 1 | Jake Hummel | Iowa State | SR | LB | 11 | 2 | 24 | 1 | 0.18 |
| 1 | Josh Thompson | Texas | SR | DB | 7 | 1 | 27 | 1 | 0.14 |
| 1 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 10 | 1 | 29 | 1 | 0.10 |
| 1 | Gavin Potter | Kansas | JR | LB | 10 | 1 | 28 | 1 | 0.10 |