2021 Big 12 Conference Leaders Interceptions - Games Won Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | JT Woods | Baylor | SR | S | 12 | 5 | 109 | 1 | 0.42 |
| 1 | Al Walcott | Baylor | JR | CB | 10 | 3 | 101 | 1 | 0.30 |
| 1 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 5 | 2 | 29 | 1 | 0.40 |
| 1 | Jason Taylor II | Okla St | JR | S | 12 | 2 | 85 | 1 | 0.17 |
| 1 | Jacobee Bryant | Kansas | FR | CB | 2 | 1 | 31 | 1 | 0.50 |
| 1 | Marquis Waters | Texas Tech | SR | DB | 3 | 1 | 72 | 1 | 0.33 |
| 1 | Josh Thompson | Texas | SR | DB | 3 | 1 | 27 | 1 | 0.33 |
| 1 | Riko Jeffers | Texas Tech | SR | LB | 7 | 1 | 13 | 1 | 0.14 |