2021 Big 12 Conference Leaders Total Offense - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brock Purdy | Iowa State | SR | QB | 9 | 132 | 2359 | 350 | 2491 | 7.12 | 276.8 |
| 2 | Spencer Sanders | Okla St | JR | QB | 10 | 437 | 2213 | 406 | 2650 | 6.53 | 265.0 |
| 3 | Jarret Doege | WVU | SR | QB | 9 | -86 | 2179 | 344 | 2093 | 6.08 | 232.6 |
| 4 | Casey Thompson | Texas | JR | QB | 9 | 106 | 1851 | 276 | 1957 | 7.09 | 217.4 |
| 5 | Skylar Thompson | Kansas St | SR | QB | 7 | -39 | 1614 | 219 | 1575 | 7.19 | 225.0 |
| 6 | Caleb Williams | Oklahoma | FR | QB | 8 | 340 | 1586 | 241 | 1926 | 7.99 | 240.8 |
| 7 | Gerry Bohanon | Baylor | JR | QB | 8 | 257 | 1528 | 242 | 1785 | 7.38 | 223.1 |
| 8 | Max Duggan | TCU | JR | QB | 7 | 242 | 1331 | 223 | 1573 | 7.05 | 224.7 |
| 9 | Henry Colombi | Texas Tech | SR | QB | 6 | 44 | 1283 | 182 | 1327 | 7.29 | 221.2 |
| 10 | Donovan Smith | Texas Tech | FR | QB | 9 | 125 | 936 | 163 | 1061 | 6.51 | 117.9 |
| 11 | Jalon Daniels | Kansas | SO | QB | 5 | 94 | 811 | 143 | 905 | 6.33 | 181.0 |
| 12 | Spencer Rattler | Oklahoma | SO | QB | 6 | 6 | 722 | 113 | 728 | 6.44 | 121.3 |
| 13 | Chandler Morris | TCU | FR | QB | 3 | 83 | 697 | 100 | 780 | 7.80 | 260.0 |
| 14 | Blake Shapen | Baylor | FR | QB | 5 | 59 | 589 | 106 | 648 | 6.11 | 129.6 |
| 15 | Jason Bean | Kansas | JR | QB | 8 | 192 | 577 | 149 | 769 | 5.16 | 96.1 |
| 16 | Hudson Card | Texas | FR | QB | 5 | 2 | 276 | 55 | 278 | 5.05 | 55.6 |
| 17 | Jaren Lewis | Kansas St | SO | QB | 3 | 3 | 148 | 25 | 151 | 6.04 | 50.3 |
| 18 | Will Howard | Kansas St | SO | QB | 3 | 119 | 128 | 40 | 247 | 6.18 | 82.3 |
| 19 | Miles Kendrick | Kansas | SR | QB | 5 | 73 | 106 | 31 | 179 | 5.77 | 35.8 |
| 20 | Garrett Greene | WVU | FR | QB | 8 | 171 | 90 | 48 | 261 | 5.44 | 32.6 |
| 21 | Sam Jackson | TCU | FR | QB | 1 | 4 | 77 | 5 | 81 | 16.20 | 81.0 |
| 22 | Shane Illingworth | Okla St | SO | QB | 2 | 6 | 70 | 12 | 76 | 6.33 | 38.0 |
| 23 | Tyler Shough | Texas Tech | JR | QB | 1 | 6 | 68 | 12 | 74 | 6.17 | 74.0 |
| 24 | Hunter Dekkers | Iowa State | FR | QB | 2 | 49 | 58 | 17 | 107 | 6.29 | 53.5 |
| 25 | Xavier Hutchinson | Iowa State | SR | WR | 9 | 18 | 49 | 3 | 67 | 22.33 | 7.4 |
| 26 | Ethan Bullock | Okla St | SR | QB | 2 | 6 | 16 | 6 | 22 | 3.67 | 11.0 |
| 27 | Taye Barber | TCU | SR | WR | 9 | 7 | 7 | 4 | 14 | 3.50 | 1.6 |
| 28 | Brennan Presley | Okla St | SO | WR | 10 | 35 | 6 | 5 | 41 | 8.20 | 4.1 |
| 28 | Tyquan Thornton | Baylor | SR | WR | 10 | -11 | 6 | 2 | -5 | -2.50 | -0.5 |
| 30 | Roschon Johnson | Texas | JR | RB | 9 | 427 | 2 | 85 | 429 | 5.05 | 47.7 |