2021 Big 12 Conference Leaders Total Offense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brock Purdy | Iowa State | SR | QB | 12 | 180 | 2989 | 457 | 3169 | 6.93 | 264.1 |
| 2 | Spencer Sanders | Okla St | JR | QB | 13 | 664 | 2831 | 538 | 3495 | 6.50 | 268.8 |
| 3 | Jarret Doege | WVU | SR | QB | 12 | -131 | 2789 | 458 | 2658 | 5.80 | 221.5 |
| 4 | Casey Thompson | Texas | JR | QB | 12 | 157 | 2113 | 316 | 2270 | 7.18 | 189.2 |
| 5 | Skylar Thompson | Kansas St | SR | QB | 9 | 4 | 2017 | 276 | 2021 | 7.32 | 224.6 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 11 | 296 | 1947 | 324 | 2243 | 6.92 | 203.9 |
| 7 | Max Duggan | TCU | JR | QB | 9 | 343 | 1841 | 311 | 2184 | 7.02 | 242.7 |
| 8 | Caleb Williams | Oklahoma | FR | QB | 10 | 375 | 1828 | 276 | 2203 | 7.98 | 220.3 |
| 9 | Henry Colombi | Texas Tech | SR | QB | 7 | 66 | 1291 | 185 | 1357 | 7.34 | 193.9 |
| 10 | Spencer Rattler | Oklahoma | SO | QB | 8 | 48 | 1240 | 200 | 1288 | 6.44 | 161.0 |
| 11 | Donovan Smith | Texas Tech | FR | QB | 11 | 155 | 1188 | 196 | 1343 | 6.85 | 122.1 |
| 12 | Jason Bean | Kansas | JR | QB | 10 | 346 | 1089 | 233 | 1435 | 6.16 | 143.5 |
| 13 | Jalon Daniels | Kansas | SO | QB | 6 | 83 | 860 | 150 | 943 | 6.29 | 157.2 |
| 14 | Tyler Shough | Texas Tech | JR | QB | 3 | 8 | 698 | 80 | 706 | 8.83 | 235.3 |
| 15 | Chandler Morris | TCU | FR | QB | 3 | 83 | 697 | 100 | 780 | 7.80 | 260.0 |
| 16 | Hudson Card | Texas | FR | QB | 8 | 16 | 590 | 109 | 606 | 5.56 | 75.8 |
| 17 | Blake Shapen | Baylor | FR | QB | 5 | 59 | 589 | 106 | 648 | 6.11 | 129.6 |
| 18 | Will Howard | Kansas St | SO | QB | 5 | 175 | 251 | 62 | 426 | 6.87 | 85.2 |
| 19 | Hunter Dekkers | Iowa State | FR | QB | 4 | 61 | 193 | 40 | 254 | 6.35 | 63.5 |
| 20 | Jaren Lewis | Kansas St | SO | QB | 4 | 3 | 154 | 28 | 157 | 5.61 | 39.3 |
| 21 | Miles Kendrick | Kansas | SR | QB | 5 | 73 | 106 | 31 | 179 | 5.77 | 35.8 |
| 22 | Garrett Greene | WVU | FR | QB | 10 | 199 | 90 | 53 | 289 | 5.45 | 28.9 |
| 23 | Sam Jackson | TCU | FR | QB | 1 | 4 | 77 | 5 | 81 | 16.20 | 81.0 |
| 24 | Shane Illingworth | Okla St | SO | QB | 3 | 6 | 70 | 12 | 76 | 6.33 | 25.3 |
| 25 | Xavier Hutchinson | Iowa State | SR | WR | 12 | 18 | 49 | 3 | 67 | 22.33 | 5.6 |
| 26 | Ethan Bullock | Okla St | SR | QB | 2 | 6 | 16 | 6 | 22 | 3.67 | 11.0 |
| 27 | Mario Williams | Oklahoma | FR | WR | 11 | 12 | 10 | 3 | 22 | 7.33 | 2.0 |
| 28 | Taye Barber | TCU | SR | WR | 11 | 7 | 7 | 4 | 14 | 3.50 | 1.3 |
| 29 | Brennan Presley | Okla St | SO | WR | 13 | 36 | 6 | 7 | 42 | 6.00 | 3.2 |
| 29 | Tyquan Thornton | Baylor | SR | WR | 13 | -11 | 6 | 2 | -5 | -2.50 | -0.4 |
| 31 | Roschon Johnson | Texas | JR | RB | 12 | 569 | 2 | 97 | 571 | 5.89 | 47.6 |