2021 Big 12 Conference Leaders Total Offense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tyler Shough | Texas Tech | JR | QB | 2 | 2 | 630 | 68 | 632 | 9.29 | 316.0 |
| 2 | Spencer Sanders | Okla St | JR | QB | 3 | 227 | 618 | 132 | 845 | 6.40 | 281.7 |
| 3 | Gerry Bohanon | Baylor | JR | QB | 2 | 19 | 379 | 59 | 398 | 6.75 | 199.0 |
| 4 | Spencer Rattler | Oklahoma | SO | QB | 1 | 7 | 304 | 47 | 311 | 6.62 | 311.0 |
| 5 | Brock Purdy | Iowa State | SR | QB | 1 | 33 | 288 | 30 | 321 | 10.70 | 321.0 |
| 6 | Max Duggan | TCU | JR | QB | 1 | 30 | 276 | 38 | 306 | 8.05 | 306.0 |
| 7 | Hudson Card | Texas | FR | QB | 2 | 1 | 253 | 31 | 254 | 8.19 | 127.0 |
| 8 | Casey Thompson | Texas | JR | QB | 2 | 7 | 205 | 25 | 212 | 8.48 | 106.0 |
| 9 | Jason Bean | Kansas | JR | QB | 1 | 100 | 189 | 37 | 289 | 7.81 | 289.0 |
| 10 | Will Howard | Kansas St | SO | QB | 1 | 56 | 123 | 22 | 179 | 8.14 | 179.0 |
| 11 | Jalon Daniels | Kansas | SO | QB | 1 | -11 | 49 | 7 | 38 | 5.43 | 38.0 |
| 12 | Hunter Dekkers | Iowa State | FR | QB | 1 | 12 | 21 | 7 | 33 | 4.71 | 33.0 |
| 13 | Mario Williams | Oklahoma | FR | WR | 1 | 0 | 10 | 1 | 10 | 10.00 | 10.0 |
| 14 | Henry Colombi | Texas Tech | SR | QB | 1 | 22 | 8 | 3 | 30 | 10.00 | 30.0 |
| 15 | Jaren Lewis | Kansas St | SO | QB | 1 | 0 | 6 | 3 | 6 | 2.00 | 6.0 |