2021 Conference USA Leaders Rushing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 8 | 247 | 872 | 3.53 | 8 | 30.88 | 109.00 |
| 2 | Rice | 8 | 251 | 1034 | 4.12 | 14 | 31.38 | 129.25 |
| 3 | Old Dominion | 8 | 266 | 944 | 3.55 | 5 | 33.25 | 118.00 |
| 4 | Middle Tennessee | 8 | 271 | 927 | 3.42 | 8 | 33.88 | 115.88 |
| 5 | Charlotte | 8 | 274 | 1311 | 4.78 | 20 | 34.25 | 163.88 |
| 6 | UTSA | 9 | 317 | 1098 | 3.46 | 11 | 35.22 | 122.00 |
| 7 | UAB | 8 | 293 | 713 | 2.43 | 8 | 36.63 | 89.13 |
| 8 | UTEP | 8 | 296 | 1171 | 3.96 | 14 | 37.00 | 146.38 |
| 9 | North Texas | 8 | 298 | 983 | 3.30 | 12 | 37.25 | 122.88 |
| 10 | Western Kentucky | 9 | 338 | 1231 | 3.64 | 14 | 37.56 | 136.78 |
| 11 | Southern Mississippi | 8 | 305 | 1515 | 4.97 | 12 | 38.13 | 189.38 |
| 12 | Louisiana Tech | 8 | 327 | 1480 | 4.53 | 18 | 40.88 | 185.00 |
| 13 | Marshall | 8 | 335 | 1419 | 4.24 | 8 | 41.88 | 177.38 |
| 14 | Florida International | 8 | 349 | 2112 | 6.05 | 26 | 43.63 | 264.00 |