2021 Conference USA Leaders Rushing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 4 | 125 | 444 | 3.55 | 1 | 31.25 | 111.00 |
| 2 | Southern Mississippi | 4 | 126 | 353 | 2.80 | 3 | 31.50 | 88.25 |
| 3 | UTSA | 4 | 128 | 325 | 2.54 | 2 | 32.00 | 81.25 |
| 4 | UTEP | 4 | 132 | 453 | 3.43 | 6 | 33.00 | 113.25 |
| 5 | Louisiana Tech | 4 | 133 | 592 | 4.45 | 6 | 33.25 | 148.00 |
| 6 | Rice | 4 | 154 | 910 | 5.91 | 16 | 38.50 | 227.50 |
| 7 | Florida International | 4 | 157 | 646 | 4.11 | 4 | 39.25 | 161.50 |
| 7 | Charlotte | 4 | 157 | 922 | 5.87 | 5 | 39.25 | 230.50 |
| 9 | Old Dominion | 4 | 160 | 556 | 3.48 | 6 | 40.00 | 139.00 |
| 10 | Middle Tennessee | 4 | 161 | 694 | 4.31 | 7 | 40.25 | 173.50 |
| 11 | North Texas | 4 | 171 | 691 | 4.04 | 6 | 42.75 | 172.75 |
| 12 | Florida Atlantic | 4 | 175 | 1014 | 5.79 | 9 | 43.75 | 253.50 |
| 13 | Western Kentucky | 3 | 140 | 674 | 4.81 | 9 | 46.67 | 224.67 |
| 14 | Marshall | 4 | 198 | 857 | 4.33 | 7 | 49.50 | 214.25 |