2021 Conference USA Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 1 | 31 | 167 | 5.39 | 2 | 31.00 | 167.00 |
| 2 | Southern Mississippi | 1 | 33 | 211 | 6.39 | 1 | 33.00 | 211.00 |
| 3 | UAB | 2 | 73 | 362 | 4.96 | 5 | 36.50 | 181.00 |
| 4 | Rice | 2 | 79 | 389 | 4.92 | 7 | 39.50 | 194.50 |
| 5 | UTSA | 1 | 40 | 156 | 3.90 | 2 | 40.00 | 156.00 |
| 6 | Old Dominion | 1 | 41 | 164 | 4.00 | 2 | 41.00 | 164.00 |
| 7 | Western Kentucky | 1 | 43 | 192 | 4.47 | 4 | 43.00 | 192.00 |
| 8 | Marshall | 1 | 51 | 220 | 4.31 | 3 | 51.00 | 220.00 |