2021 Conference USA Leaders Rushing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Rice | 8 | 282 | 1542 | 5.47 | 24 | 35.25 | 192.75 |
| 2 | Middle Tennessee | 6 | 215 | 1004 | 4.67 | 11 | 35.83 | 167.33 |
| 3 | Southern Mississippi | 9 | 334 | 1496 | 4.48 | 14 | 37.11 | 166.22 |
| 4 | Louisiana Tech | 9 | 338 | 1554 | 4.60 | 19 | 37.56 | 172.67 |
| 5 | North Texas | 7 | 277 | 1185 | 4.28 | 14 | 39.57 | 169.29 |
| 5 | Florida Atlantic | 7 | 277 | 1467 | 5.30 | 14 | 39.57 | 209.57 |
| 7 | UAB | 4 | 159 | 570 | 3.58 | 6 | 39.75 | 142.50 |
| 8 | Charlotte | 7 | 279 | 1519 | 5.44 | 20 | 39.86 | 217.00 |
| 9 | UTEP | 6 | 241 | 1118 | 4.64 | 16 | 40.17 | 186.33 |
| 10 | Old Dominion | 7 | 290 | 1050 | 3.62 | 8 | 41.43 | 150.00 |
| 11 | Florida International | 11 | 470 | 2662 | 5.66 | 30 | 42.73 | 242.00 |
| 12 | Marshall | 6 | 275 | 1123 | 4.08 | 14 | 45.83 | 187.17 |
| 13 | Western Kentucky | 5 | 240 | 1161 | 4.84 | 16 | 48.00 | 232.20 |
| 14 | UTSA | 2 | 100 | 496 | 4.96 | 8 | 50.00 | 248.00 |