2025 Atlantic Coast Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 09/11/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | NC State | 1 | 30 | 383 | 74 | 413 | 5.58 | 413.0 |
| 2 | Pittsburgh | 2 | 69 | 348 | 126 | 417 | 3.31 | 208.5 |
| 3 | Virginia | 1 | 91 | 163 | 67 | 254 | 3.79 | 254.0 |
| 4 | California | 2 | 117 | 388 | 119 | 505 | 4.24 | 252.5 |
| 5 | Boston College | 2 | 165 | 383 | 130 | 548 | 4.22 | 274.0 |
| 6 | Miami (FL) | 2 | 185 | 320 | 109 | 505 | 4.63 | 252.5 |
| 7 | Clemson | 2 | 186 | 471 | 133 | 657 | 4.94 | 328.5 |
| 8 | Florida State | 2 | 192 | 346 | 121 | 538 | 4.45 | 269.0 |
| 8 | Wake Forest | 2 | 192 | 353 | 152 | 545 | 3.59 | 272.5 |
| 10 | Louisville | 2 | 200 | 213 | 131 | 413 | 3.15 | 206.5 |
| 11 | Stanford | 2 | 253 | 385 | 132 | 638 | 4.83 | 319.0 |
| 12 | Georgia Tech | 2 | 263 | 368 | 137 | 631 | 4.61 | 315.5 |
| 13 | SMU | 2 | 268 | 684 | 172 | 952 | 5.53 | 476.0 |
| 14 | North Carolina | 2 | 279 | 534 | 143 | 813 | 5.69 | 406.5 |
| 15 | Duke | 2 | 286 | 408 | 135 | 694 | 5.14 | 347.0 |
| 16 | Virginia Tech | 2 | 381 | 437 | 113 | 818 | 7.24 | 409.0 |
| 17 | Syracuse | 2 | 388 | 521 | 146 | 909 | 6.23 | 454.5 |