2020 Atlantic Coast Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/11/2021
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 1 | 1 | 136 | 55 | 137 | 2.49 | 137.0 |
| 2 | Virginia | 1 | 62 | 278 | 77 | 340 | 4.42 | 340.0 |
| 3 | Florida State | 1 | 63 | 244 | 53 | 307 | 5.79 | 307.0 |
| 4 | Louisville | 1 | 119 | 129 | 58 | 248 | 4.28 | 248.0 |
| 5 | Boston College | 1 | 128 | 229 | 69 | 357 | 5.17 | 357.0 |
| 6 | Duke | 1 | 177 | 171 | 87 | 348 | 4.00 | 348.0 |
| 7 | Miami (Florida) | 2 | 193 | 510 | 144 | 703 | 4.88 | 351.5 |
| 8 | Wake Forest | 2 | 242 | 386 | 138 | 628 | 4.55 | 314.0 |
| 9 | Georgia Tech | 1 | 243 | 417 | 92 | 660 | 7.17 | 660.0 |
| 10 | Notre Dame | 2 | 246 | 422 | 117 | 668 | 5.71 | 334.0 |
| 11 | Virginia Tech | 1 | 249 | 217 | 80 | 466 | 5.83 | 466.0 |
| 12 | Syracuse | 1 | 338 | 182 | 68 | 520 | 7.65 | 520.0 |
| 13 | Clemson | 2 | 340 | 461 | 131 | 801 | 6.11 | 400.5 |
| 14 | North Carolina | 2 | 362 | 348 | 120 | 710 | 5.92 | 355.0 |
| 15 | North Carolina State | 2 | 395 | 264 | 138 | 659 | 4.78 | 329.5 |