2025 Big 12 Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Arizona | 1 | 105 | 88 | 53 | 193 | 3.64 | 193.0 |
| 2 | Utah | 1 | 84 | 136 | 50 | 220 | 4.40 | 220.0 |
| 3 | BYU | 1 | 19 | 142 | 56 | 161 | 2.88 | 161.0 |
| 4 | TCU | 1 | 50 | 172 | 49 | 222 | 4.53 | 222.0 |
| 5 | Houston | 1 | 96 | 204 | 58 | 300 | 5.17 | 300.0 |
| 6 | Cincinnati | 1 | 110 | 243 | 78 | 353 | 4.53 | 353.0 |
| 7 | Arizona State | 1 | 66 | 279 | 63 | 345 | 5.48 | 345.0 |
| 8 | Texas Tech | 1 | 8 | 281 | 68 | 289 | 4.25 | 289.0 |
| 9 | West Virginia | 1 | 46 | 303 | 72 | 349 | 4.85 | 349.0 |
| 10 | Oklahoma State | 1 | 312 | 319 | 62 | 631 | 10.18 | 631.0 |
| 11 | Kansas | 1 | 261 | 334 | 86 | 595 | 6.92 | 595.0 |
| 12 | Iowa State | 2 | 241 | 356 | 120 | 597 | 4.98 | 298.5 |
| 13 | Kansas State | 2 | 364 | 361 | 153 | 725 | 4.74 | 362.5 |
| 14 | Colorado | 2 | 529 | 365 | 145 | 894 | 6.17 | 447.0 |
| 15 | Baylor | 2 | 470 | 403 | 135 | 873 | 6.47 | 436.5 |