2025 Big 12 Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | BYU | 2 | 14 | 198 | 100 | 212 | 2.12 | 106.0 |
| 2 | Houston | 2 | 216 | 156 | 124 | 372 | 3.00 | 186.0 |
| 3 | Arizona | 2 | 183 | 291 | 131 | 474 | 3.62 | 237.0 |
| 4 | UCF | 2 | 325 | 197 | 131 | 522 | 3.98 | 261.0 |
| 5 | Utah | 3 | 270 | 402 | 165 | 672 | 4.07 | 224.0 |
| 6 | TCU | 2 | 227 | 448 | 124 | 675 | 5.44 | 337.5 |
| 7 | Kansas State | 2 | 339 | 347 | 154 | 686 | 4.45 | 343.0 |
| 8 | Texas Tech | 3 | 124 | 568 | 186 | 692 | 3.72 | 230.7 |
| 9 | Iowa State | 3 | 374 | 431 | 187 | 805 | 4.30 | 268.3 |
| 10 | Cincinnati | 3 | 276 | 551 | 200 | 827 | 4.14 | 275.7 |
| 11 | Oklahoma State | 2 | 428 | 428 | 117 | 856 | 7.32 | 428.0 |
| 12 | Colorado | 2 | 404 | 455 | 134 | 859 | 6.41 | 429.5 |
| 13 | West Virginia | 3 | 281 | 620 | 210 | 901 | 4.29 | 300.3 |
| 14 | Kansas | 3 | 351 | 603 | 192 | 954 | 4.97 | 318.0 |
| 15 | Arizona State | 3 | 274 | 705 | 212 | 979 | 4.62 | 326.3 |
| 16 | Baylor | 3 | 565 | 503 | 193 | 1068 | 5.53 | 356.0 |