2025 Big 12 Conference Leaders Total Defense - Games vs. Conference Teams Only through 09/13/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Arizona | 1 | 105 | 88 | 53 | 193 | 3.64 | 193.0 |
| 2 | Houston | 1 | 96 | 204 | 58 | 300 | 5.17 | 300.0 |
| 3 | Iowa State | 1 | 110 | 273 | 57 | 383 | 6.72 | 383.0 |
| 4 | Colorado | 1 | 209 | 222 | 77 | 431 | 5.60 | 431.0 |
| 5 | Kansas State | 2 | 364 | 361 | 153 | 725 | 4.74 | 362.5 |