2025 Conference USA Leaders Opponent First Downs - Games in August/September Only through 12/13/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 5 | 40 | 37 | 18 | 95 | 19.0 |
| 2 | UTEP | 5 | 44 | 40 | 10 | 94 | 18.8 |
| 3 | Liberty | 5 | 53 | 41 | 5 | 99 | 19.8 |
| 4 | FIU | 4 | 33 | 44 | 7 | 84 | 21.0 |
| 4 | New Mexico State | 4 | 36 | 44 | 12 | 92 | 23.0 |
| 6 | Middle Tennessee State | 5 | 46 | 46 | 8 | 100 | 20.0 |
| 6 | Jacksonville State | 5 | 53 | 46 | 9 | 108 | 21.6 |
| 8 | Delaware | 4 | 28 | 50 | 7 | 85 | 21.3 |
| 9 | Missouri State | 5 | 36 | 53 | 13 | 102 | 20.4 |
| 10 | Kennesaw State | 5 | 41 | 55 | 10 | 106 | 21.2 |
| 11 | Louisiana Tech | 5 | 29 | 57 | 16 | 102 | 20.4 |
| 12 | Sam Houston State | 4 | 31 | 60 | 5 | 96 | 24.0 |