2022 Atlantic Coast Conference Leaders Rushing Defense - Games in August/September Only through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 123 | 314 | 2.55 | 1 | 30.75 | 78.50 |
| 2 | Virginia | 4 | 150 | 532 | 3.55 | 2 | 37.50 | 133.00 |
| 3 | North Carolina State | 4 | 100 | 327 | 3.27 | 3 | 25.00 | 81.75 |
| 3 | Miami (Florida) | 4 | 120 | 340 | 2.83 | 3 | 30.00 | 85.00 |
| 3 | Virginia Tech | 4 | 129 | 344 | 2.67 | 3 | 32.25 | 86.00 |
| 3 | Duke | 4 | 143 | 562 | 3.93 | 3 | 35.75 | 140.50 |
| 7 | Wake Forest | 4 | 151 | 559 | 3.70 | 4 | 37.75 | 139.75 |
| 7 | Florida State | 4 | 138 | 579 | 4.20 | 4 | 34.50 | 144.75 |
| 9 | Syracuse | 4 | 108 | 444 | 4.11 | 5 | 27.00 | 111.00 |
| 9 | Louisville | 4 | 150 | 653 | 4.35 | 5 | 37.50 | 163.25 |
| 11 | Pittsburgh | 4 | 119 | 394 | 3.31 | 6 | 29.75 | 98.50 |
| 12 | North Carolina | 4 | 175 | 866 | 4.95 | 7 | 43.75 | 216.50 |
| 13 | Boston College | 4 | 151 | 625 | 4.14 | 9 | 37.75 | 156.25 |
| 14 | Georgia Tech | 4 | 198 | 838 | 4.23 | 10 | 49.50 | 209.50 |