2022 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Duke | 1 | 33 | 120 | 3.64 | 1 | 33.00 | 120.00 |
| 1 | Wake Forest | 2 | 73 | 300 | 4.11 | 1 | 36.50 | 150.00 |
| 1 | Virginia | 1 | 48 | 189 | 3.94 | 1 | 48.00 | 189.00 |
| 4 | Florida State | 2 | 74 | 306 | 4.14 | 2 | 37.00 | 153.00 |
| 5 | North Carolina State | 2 | 66 | 351 | 5.32 | 3 | 33.00 | 175.50 |
| 6 | Pittsburgh | 2 | 63 | 219 | 3.48 | 4 | 31.50 | 109.50 |
| 7 | Louisville | 3 | 119 | 605 | 5.08 | 5 | 39.67 | 201.67 |
| 8 | Virginia Tech | 1 | 43 | 326 | 7.58 | 6 | 43.00 | 326.00 |
| 9 | Clemson | 4 | 150 | 648 | 4.32 | 7 | 37.50 | 162.00 |
| 9 | Georgia Tech | 4 | 155 | 735 | 4.74 | 7 | 38.75 | 183.75 |
| 11 | Boston College | 3 | 105 | 605 | 5.76 | 9 | 35.00 | 201.67 |
| 11 | Miami (Florida) | 3 | 131 | 678 | 5.18 | 9 | 43.67 | 226.00 |
| 11 | Syracuse | 4 | 204 | 930 | 4.56 | 9 | 51.00 | 232.50 |
| 14 | North Carolina | 4 | 134 | 695 | 5.19 | 11 | 33.50 | 173.75 |