2022 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 3 | 112 | 457 | 4.08 | 1 | 37.33 | 152.33 |
| 2 | North Carolina State | 5 | 141 | 403 | 2.86 | 3 | 28.20 | 80.60 |
| 2 | Miami (Florida) | 4 | 120 | 340 | 2.83 | 3 | 30.00 | 85.00 |
| 2 | Louisville | 5 | 189 | 610 | 3.23 | 3 | 37.80 | 122.00 |
| 5 | Virginia Tech | 4 | 132 | 455 | 3.45 | 4 | 33.00 | 113.75 |
| 5 | Wake Forest | 5 | 192 | 710 | 3.70 | 4 | 38.40 | 142.00 |
| 7 | Duke | 5 | 179 | 690 | 3.85 | 5 | 35.80 | 138.00 |
| 8 | Syracuse | 5 | 169 | 512 | 3.03 | 6 | 33.80 | 102.40 |
| 8 | Clemson | 5 | 170 | 573 | 3.37 | 6 | 34.00 | 114.60 |
| 10 | Boston College | 4 | 148 | 689 | 4.66 | 7 | 37.00 | 172.25 |
| 10 | Florida State | 5 | 201 | 879 | 4.37 | 7 | 40.20 | 175.80 |
| 12 | Pittsburgh | 5 | 147 | 522 | 3.55 | 8 | 29.40 | 104.40 |
| 13 | North Carolina | 5 | 207 | 1075 | 5.19 | 9 | 41.40 | 215.00 |
| 13 | Georgia Tech | 4 | 199 | 983 | 4.94 | 9 | 49.75 | 245.75 |