2021 Atlantic Coast Conference Leaders Rushing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 154 | 467 | 3.03 | 0 | 38.50 | 116.75 |
| 1 | Wake Forest | 4 | 134 | 477 | 3.56 | 0 | 33.50 | 119.25 |
| 3 | North Carolina State | 4 | 102 | 321 | 3.15 | 1 | 25.50 | 80.25 |
| 4 | Syracuse | 4 | 147 | 341 | 2.32 | 2 | 36.75 | 85.25 |
| 4 | Virginia Tech | 4 | 135 | 552 | 4.09 | 2 | 33.75 | 138.00 |
| 6 | Boston College | 4 | 124 | 392 | 3.16 | 4 | 31.00 | 98.00 |
| 7 | Georgia Tech | 4 | 161 | 540 | 3.35 | 5 | 40.25 | 135.00 |
| 7 | Miami (Florida) | 5 | 179 | 677 | 3.78 | 5 | 35.80 | 135.40 |
| 9 | Pittsburgh | 4 | 137 | 438 | 3.20 | 6 | 34.25 | 109.50 |
| 9 | Florida State | 4 | 173 | 529 | 3.06 | 6 | 43.25 | 132.25 |
| 9 | Duke | 4 | 160 | 723 | 4.52 | 6 | 40.00 | 180.75 |
| 12 | Louisville | 4 | 133 | 691 | 5.20 | 7 | 33.25 | 172.75 |
| 13 | North Carolina | 4 | 153 | 584 | 3.82 | 8 | 38.25 | 146.00 |
| 13 | Virginia | 5 | 196 | 974 | 4.97 | 8 | 39.20 | 194.80 |