2021 Big Ten Conference Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wisconsin | 13 | 793 | 2266 | 746 | 3059 | 4.10 | 235.3 |
| 2 | Minnesota | 13 | 1268 | 2356 | 745 | 3624 | 4.86 | 278.8 |
| 3 | Nebraska | 11 | 1634 | 2466 | 770 | 4100 | 5.32 | 372.7 |
| 4 | Penn State | 12 | 1941 | 2376 | 905 | 4317 | 4.77 | 359.8 |
| 5 | Indiana | 11 | 1712 | 2632 | 757 | 4344 | 5.74 | 394.9 |
| 6 | Illinois | 12 | 1822 | 2582 | 840 | 4404 | 5.24 | 367.0 |
| 7 | Iowa | 14 | 1602 | 3003 | 976 | 4605 | 4.72 | 328.9 |
| 8 | Michigan | 14 | 1770 | 2862 | 939 | 4632 | 4.93 | 330.9 |
| 9 | Purdue | 13 | 2035 | 2713 | 857 | 4748 | 5.54 | 365.2 |
| 10 | Ohio State | 13 | 1648 | 3196 | 909 | 4844 | 5.33 | 372.6 |
| 11 | Rutgers | 12 | 1934 | 2956 | 807 | 4890 | 6.06 | 407.5 |
| 12 | Northwestern | 11 | 2528 | 2460 | 782 | 4988 | 6.38 | 453.5 |
| 13 | Maryland | 12 | 1946 | 3154 | 859 | 5100 | 5.94 | 425.0 |
| 14 | Michigan State | 12 | 1344 | 4085 | 948 | 5429 | 5.73 | 452.4 |