2021 Purdue Boilermakers Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 2035 | 2713 | 857 | 4748 | 5.54 | 365.2 |
| at Home | 6 | 906 | 1029 | 369 | 1935 | 5.24 | 322.5 |
| on Road/Neutral Site | 7 | 1129 | 1684 | 488 | 2813 | 5.76 | 401.9 |
| in Wins | 9 | 1237 | 1908 | 610 | 3145 | 5.16 | 349.4 |
| in Losses | 4 | 798 | 805 | 247 | 1603 | 6.49 | 400.8 |
| vs. Conference | 9 | 1442 | 1728 | 564 | 3170 | 5.62 | 352.2 |
| vs. Non-Conference | 4 | 593 | 985 | 293 | 1578 | 5.39 | 394.5 |
| vs. Ranked (AP) | 4 | 641 | 1055 | 260 | 1696 | 6.52 | 424.0 |
| vs. Unranked (AP) | 9 | 1394 | 1658 | 597 | 3052 | 5.11 | 339.1 |
| vs. FBS (I-A) | 13 | 2035 | 2713 | 857 | 4748 | 5.54 | 365.2 |
| vs. FCS (I-AA) | 0 | 0 | 0 | 0 | 0 | - | - |
| vs. FBS Winning | 8 | 1414 | 1939 | 540 | 3353 | 6.21 | 419.1 |
| vs. FBS Non-Winning | 5 | 621 | 774 | 317 | 1395 | 4.40 | 279.0 |
| vs. FBS Power 5 | 11 | 1800 | 2391 | 732 | 4191 | 5.73 | 381.0 |
| vs. FBS non-Power 5 | 2 | 235 | 322 | 125 | 557 | 4.46 | 278.5 |
| in August/September | 4 | 487 | 707 | 257 | 1194 | 4.65 | 298.5 |
| in October | 4 | 621 | 685 | 232 | 1306 | 5.63 | 326.5 |
| in November | 4 | 646 | 943 | 263 | 1589 | 6.04 | 397.3 |
| in December/January | 1 | 281 | 378 | 105 | 659 | 6.28 | 659.0 |