2021 Big Ten Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Minnesota | 4 | 173 | 629 | 225 | 802 | 3.56 | 200.5 |
| 2 | Wisconsin | 4 | 258 | 561 | 217 | 819 | 3.77 | 204.8 |
| 3 | Indiana | 3 | 276 | 771 | 197 | 1047 | 5.31 | 349.0 |
| 4 | Nebraska | 3 | 458 | 601 | 210 | 1059 | 5.04 | 353.0 |
| 5 | Northwestern | 3 | 421 | 657 | 218 | 1078 | 4.94 | 359.3 |
| 6 | Maryland | 4 | 386 | 802 | 259 | 1188 | 4.59 | 297.0 |
| 7 | Iowa | 4 | 383 | 825 | 287 | 1208 | 4.21 | 302.0 |
| 8 | Rutgers | 4 | 487 | 741 | 260 | 1228 | 4.72 | 307.0 |
| 9 | Illinois | 3 | 431 | 894 | 204 | 1325 | 6.50 | 441.7 |
| 10 | Michigan | 4 | 527 | 861 | 257 | 1388 | 5.40 | 347.0 |
| 11 | Penn State | 4 | 662 | 731 | 288 | 1393 | 4.84 | 348.3 |
| 12 | Michigan State | 4 | 395 | 1183 | 307 | 1578 | 5.14 | 394.5 |
| 12 | Purdue | 4 | 593 | 985 | 293 | 1578 | 5.39 | 394.5 |
| 14 | Ohio State | 4 | 644 | 1054 | 297 | 1698 | 5.72 | 424.5 |