2021 Big Ten Conference Leaders Total Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Nebraska | 5 | 866 | 915 | 306 | 1781 | 5.82 | 356.2 |
| 2 | Minnesota | 6 | 479 | 974 | 343 | 1453 | 4.24 | 242.2 |
| 3 | Wisconsin | 6 | 246 | 995 | 342 | 1241 | 3.63 | 206.8 |
| 4 | Illinois | 5 | 494 | 1148 | 337 | 1642 | 4.87 | 328.4 |
| 5 | Ohio State | 6 | 984 | 1195 | 394 | 2179 | 5.53 | 363.2 |
| 6 | Maryland | 6 | 1155 | 1329 | 416 | 2484 | 5.97 | 414.0 |
| 7 | Penn State | 6 | 1035 | 1422 | 479 | 2457 | 5.13 | 409.5 |
| 8 | Iowa | 7 | 904 | 1481 | 471 | 2385 | 5.06 | 340.7 |
| 9 | Rutgers | 7 | 796 | 1550 | 470 | 2346 | 4.99 | 335.1 |
| 10 | Michigan | 7 | 966 | 1561 | 481 | 2527 | 5.25 | 361.0 |
| 11 | Indiana | 6 | 894 | 1631 | 417 | 2525 | 6.06 | 420.8 |
| 12 | Northwestern | 6 | 1467 | 1637 | 450 | 3104 | 6.90 | 517.3 |
| 13 | Purdue | 7 | 1129 | 1684 | 488 | 2813 | 5.76 | 401.9 |
| 14 | Michigan State | 7 | 782 | 2280 | 556 | 3062 | 5.51 | 437.4 |