2021 Big Ten Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Illinois | 9 | 1391 | 1688 | 636 | 3079 | 4.84 | 342.1 |
| 2 | Wisconsin | 9 | 535 | 1705 | 529 | 2240 | 4.23 | 248.9 |
| 3 | Minnesota | 9 | 1095 | 1727 | 520 | 2822 | 5.43 | 313.6 |
| 4 | Purdue | 9 | 1442 | 1728 | 564 | 3170 | 5.62 | 352.2 |
| 5 | Penn State | 9 | 1337 | 1867 | 677 | 3204 | 4.73 | 356.0 |
| 6 | Northwestern | 9 | 2138 | 1941 | 621 | 4079 | 6.57 | 453.2 |
| 7 | Michigan | 10 | 1243 | 2001 | 682 | 3244 | 4.76 | 324.4 |
| 8 | Nebraska | 9 | 1305 | 2028 | 618 | 3333 | 5.39 | 370.3 |
| 9 | Indiana | 9 | 1501 | 2057 | 621 | 3558 | 5.73 | 395.3 |
| 10 | Ohio State | 9 | 1004 | 2142 | 612 | 3146 | 5.14 | 349.6 |
| 11 | Iowa | 10 | 1219 | 2178 | 689 | 3397 | 4.93 | 339.7 |
| 12 | Rutgers | 9 | 1606 | 2313 | 606 | 3919 | 6.47 | 435.4 |
| 13 | Maryland | 9 | 1626 | 2432 | 651 | 4058 | 6.23 | 450.9 |
| 14 | Michigan State | 9 | 1116 | 3039 | 718 | 4155 | 5.79 | 461.7 |