2021 Big Ten Conference Leaders Total Defense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Purdue | 4 | 621 | 685 | 232 | 1306 | 5.63 | 326.5 |
| 2 | Michigan | 4 | 482 | 787 | 236 | 1269 | 5.38 | 317.3 |
| 3 | Minnesota | 4 | 435 | 899 | 253 | 1334 | 5.27 | 333.5 |
| 4 | Rutgers | 4 | 699 | 1129 | 259 | 1828 | 7.06 | 457.0 |
| 5 | Illinois | 4 | 764 | 614 | 270 | 1378 | 5.10 | 344.5 |
| 6 | Iowa | 4 | 456 | 836 | 279 | 1292 | 4.63 | 323.0 |
| 7 | Ohio State | 4 | 234 | 955 | 281 | 1189 | 4.23 | 297.3 |
| 8 | Maryland | 4 | 841 | 1082 | 287 | 1923 | 6.70 | 480.8 |
| 9 | Penn State | 4 | 697 | 733 | 290 | 1430 | 4.93 | 357.5 |
| 10 | Indiana | 4 | 575 | 1111 | 293 | 1686 | 5.75 | 421.5 |
| 11 | Wisconsin | 5 | 328 | 758 | 294 | 1086 | 3.69 | 217.2 |
| 12 | Northwestern | 4 | 1092 | 686 | 296 | 1778 | 6.01 | 444.5 |
| 13 | Nebraska | 4 | 539 | 958 | 301 | 1497 | 4.97 | 374.3 |
| 14 | Michigan State | 4 | 463 | 1348 | 338 | 1811 | 5.36 | 452.8 |