2021 American Athletic Conference Leaders Passing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 2 | 44 | 23 | 52.3 | 204 | 4.6 | 2 | 1 | 101.66 | 22.0 | 102.0 |
| 2 | Tulsa | 2 | 51 | 30 | 58.8 | 358 | 7.0 | 3 | 2 | 129.36 | 25.5 | 179.0 |
| 3 | Cincinnati | 2 | 68 | 34 | 50.0 | 405 | 6.0 | 5 | 4 | 112.53 | 34.0 | 202.5 |
| 4 | East Carolina | 1 | 24 | 13 | 54.2 | 225 | 9.4 | 1 | 1 | 138.34 | 24.0 | 225.0 |
| 5 | Houston | 2 | 61 | 36 | 59.0 | 458 | 7.5 | 2 | 0 | 132.91 | 30.5 | 229.0 |
| 6 | UCF | 2 | 76 | 38 | 50.0 | 481 | 6.3 | 2 | 1 | 109.22 | 38.0 | 240.5 |
| 7 | South Florida | 2 | 51 | 34 | 66.7 | 535 | 10.5 | 5 | 3 | 175.38 | 25.5 | 267.5 |
| 8 | SMU | 1 | 28 | 16 | 57.1 | 276 | 9.9 | 3 | 0 | 175.30 | 28.0 | 276.0 |
| 9 | Tulane | 2 | 73 | 54 | 74.0 | 649 | 8.9 | 4 | 2 | 161.25 | 36.5 | 324.5 |
| 10 | Memphis | 1 | 67 | 50 | 74.6 | 419 | 6.3 | 3 | 0 | 141.94 | 67.0 | 419.0 |