2021 American Athletic Conference Leaders Passing Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | UCF | 1 | 23 | 13 | 56.5 | 140 | 6.1 | 1 | 0 | 122.00 | 23.0 | 140.0 |
| 2 | Houston | 1 | 17 | 11 | 64.7 | 190 | 11.2 | 3 | 0 | 216.83 | 17.0 | 190.0 |
| 3 | Tulsa | 4 | 103 | 64 | 62.1 | 893 | 8.7 | 7 | 4 | 149.63 | 25.8 | 223.3 |
| 4 | Cincinnati | 3 | 100 | 57 | 57.0 | 688 | 6.9 | 6 | 4 | 126.59 | 33.3 | 229.3 |
| 5 | East Carolina | 2 | 57 | 36 | 63.2 | 470 | 8.2 | 4 | 2 | 148.57 | 28.5 | 235.0 |
| 6 | Navy | 3 | 91 | 64 | 70.3 | 713 | 7.8 | 4 | 1 | 148.45 | 30.3 | 237.7 |
| 7 | Temple | 2 | 67 | 45 | 67.2 | 492 | 7.3 | 5 | 0 | 153.47 | 33.5 | 246.0 |
| 8 | Memphis | 1 | 33 | 20 | 60.6 | 264 | 8.0 | 1 | 2 | 125.69 | 33.0 | 264.0 |
| 9 | Tulane | 4 | 136 | 94 | 69.1 | 1164 | 8.6 | 10 | 3 | 160.87 | 34.0 | 291.0 |
| 10 | South Florida | 4 | 117 | 89 | 76.1 | 1226 | 10.5 | 10 | 2 | 188.88 | 29.3 | 306.5 |
| 11 | SMU | 2 | 68 | 48 | 70.6 | 707 | 10.4 | 9 | 0 | 201.60 | 34.0 | 353.5 |