2021 American Athletic Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 4 | 551 | 800 | 242 | 1351 | 5.58 | 337.8 |
| 2 | South Florida | 4 | 931 | 1088 | 263 | 2019 | 7.68 | 504.8 |
| 3 | Temple | 4 | 693 | 431 | 267 | 1124 | 4.21 | 281.0 |
| 4 | Houston | 5 | 531 | 749 | 286 | 1280 | 4.48 | 256.0 |
| 5 | SMU | 4 | 546 | 1224 | 287 | 1770 | 6.17 | 442.5 |
| 6 | East Carolina | 4 | 670 | 1307 | 302 | 1977 | 6.55 | 494.3 |
| 7 | Tulane | 4 | 725 | 1073 | 306 | 1798 | 5.88 | 449.5 |
| 8 | Tulsa | 5 | 663 | 1166 | 327 | 1829 | 5.59 | 365.8 |
| 9 | Memphis | 4 | 452 | 1394 | 335 | 1846 | 5.51 | 461.5 |
| 10 | UCF | 5 | 577 | 1173 | 350 | 1750 | 5.00 | 350.0 |
| 11 | Cincinnati | 5 | 799 | 920 | 365 | 1719 | 4.71 | 343.8 |