2021 American Athletic Conference Leaders Total Defense - Games vs. FCS (I-AA) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 1 | 53 | 49 | 46 | 102 | 2.22 | 102.0 |
| 2 | Temple | 1 | 123 | 36 | 57 | 159 | 2.79 | 159.0 |
| 3 | Tulane | 1 | 44 | 184 | 62 | 228 | 3.68 | 228.0 |
| 3 | Memphis | 1 | 100 | 199 | 62 | 299 | 4.82 | 299.0 |
| 5 | SMU | 1 | 119 | 213 | 64 | 332 | 5.19 | 332.0 |
| 6 | UCF | 1 | 24 | 255 | 65 | 279 | 4.29 | 279.0 |
| 7 | Cincinnati | 1 | 93 | 149 | 66 | 242 | 3.67 | 242.0 |
| 8 | South Florida | 1 | 132 | 248 | 78 | 380 | 4.87 | 380.0 |
| 9 | Tulsa | 1 | 88 | 311 | 82 | 399 | 4.87 | 399.0 |
| 10 | East Carolina | 1 | 131 | 390 | 100 | 521 | 5.21 | 521.0 |