2021 American Athletic Conference Leaders Total Defense - Games Lost Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 1 | 301 | 181 | 75 | 482 | 6.43 | 482.0 |
| 2 | Houston | 2 | 355 | 421 | 97 | 776 | 8.00 | 388.0 |
| 3 | SMU | 4 | 497 | 1383 | 307 | 1880 | 6.12 | 470.0 |
| 4 | UCF | 4 | 1116 | 898 | 315 | 2014 | 6.39 | 503.5 |
| 5 | East Carolina | 5 | 720 | 1148 | 321 | 1868 | 5.82 | 373.6 |
| 6 | Tulsa | 6 | 1109 | 1204 | 400 | 2313 | 5.78 | 385.5 |
| 7 | Memphis | 6 | 1194 | 1359 | 476 | 2553 | 5.36 | 425.5 |
| 8 | Navy | 8 | 1087 | 2069 | 488 | 3156 | 6.47 | 394.5 |
| 9 | Temple | 9 | 2195 | 1603 | 648 | 3798 | 5.86 | 422.0 |
| 10 | South Florida | 10 | 2307 | 2729 | 696 | 5036 | 7.24 | 503.6 |
| 11 | Tulane | 10 | 1734 | 2897 | 750 | 4631 | 6.17 | 463.1 |