2021 Big 12 Conference Leaders Passing - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Rattler | Oklahoma | SO | QB | 1 | 39 | 30 | 76.9 | 304 | 7.8 | 1 | 2 | 140.60 | 39.0 | 304.0 |
| 2 | Spencer Sanders | Okla St | JR | QB | 3 | 90 | 55 | 61.1 | 618 | 6.9 | 6 | 1 | 138.57 | 30.0 | 206.0 |
| 3 | Tyler Shough | Texas Tech | JR | QB | 2 | 59 | 43 | 72.9 | 630 | 10.7 | 5 | 0 | 190.55 | 29.5 | 315.0 |
| 4 | Max Duggan | TCU | JR | QB | 1 | 28 | 16 | 57.1 | 276 | 9.9 | 3 | 0 | 175.30 | 28.0 | 276.0 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 2 | 52 | 33 | 63.5 | 379 | 7.3 | 1 | 1 | 127.18 | 26.0 | 189.5 |
| 6 | Brock Purdy | Iowa State | SR | QB | 1 | 24 | 21 | 87.5 | 288 | 12.0 | 3 | 0 | 229.55 | 24.0 | 288.0 |
| 6 | Jason Bean | Kansas | JR | QB | 1 | 24 | 12 | 50.0 | 189 | 7.9 | 0 | 0 | 116.15 | 24.0 | 189.0 |
| 8 | Hudson Card | Texas | FR | QB | 2 | 24 | 16 | 66.7 | 253 | 10.5 | 2 | 0 | 182.72 | 12.0 | 126.5 |
| 9 | Casey Thompson | Texas | JR | QB | 2 | 23 | 19 | 82.6 | 205 | 8.9 | 3 | 1 | 191.82 | 11.5 | 102.5 |
| 10 | Will Howard | Kansas St | SO | QB | 1 | 10 | 7 | 70.0 | 123 | 12.3 | 1 | 0 | 206.32 | 10.0 | 123.0 |
| 11 | Hunter Dekkers | Iowa State | FR | QB | 1 | 6 | 2 | 33.3 | 21 | 3.5 | 0 | 0 | 62.73 | 6.0 | 21.0 |
| 12 | Jalon Daniels | Kansas | SO | QB | 1 | 5 | 3 | 60.0 | 49 | 9.8 | 0 | 0 | 142.32 | 5.0 | 49.0 |
| 13 | Jaren Lewis | Kansas St | SO | QB | 1 | 3 | 2 | 66.7 | 6 | 2.0 | 0 | 0 | 83.47 | 3.0 | 6.0 |
| 14 | Mario Williams | Oklahoma | FR | WR | 1 | 1 | 1 | 100.0 | 10 | 10.0 | 0 | 0 | 184.00 | 1.0 | 10.0 |
Note: To qualify, player must have played in 75% of his team's games.