2021 Big 12 Conference Leaders Passing - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Rattler | Oklahoma | SO | QB | 3 | 99 | 74 | 74.7 | 761 | 7.7 | 7 | 2 | 158.61 | 33.0 | 253.7 |
| 2 | Spencer Sanders | Okla St | JR | QB | 3 | 90 | 55 | 61.1 | 618 | 6.9 | 6 | 1 | 138.57 | 30.0 | 206.0 |
| 3 | Jarret Doege | WVU | SR | QB | 4 | 119 | 71 | 59.7 | 869 | 7.3 | 6 | 4 | 130.93 | 29.8 | 217.3 |
| 4 | Brock Purdy | Iowa State | SR | QB | 4 | 116 | 78 | 67.2 | 829 | 7.1 | 4 | 4 | 131.75 | 29.0 | 207.3 |
| 5 | Jason Bean | Kansas | JR | QB | 3 | 82 | 48 | 58.5 | 675 | 8.2 | 4 | 2 | 138.91 | 27.3 | 225.0 |
| 6 | Tyler Shough | Texas Tech | JR | QB | 3 | 81 | 55 | 67.9 | 804 | 9.9 | 6 | 2 | 170.78 | 27.0 | 268.0 |
| 7 | Max Duggan | TCU | JR | QB | 3 | 78 | 47 | 60.3 | 717 | 9.2 | 7 | 2 | 161.95 | 26.0 | 239.0 |
| 8 | Gerry Bohanon | Baylor | JR | QB | 4 | 92 | 57 | 62.0 | 666 | 7.2 | 5 | 2 | 136.36 | 23.0 | 166.5 |
| 9 | Skylar Thompson | Kansas St | SR | QB | 3 | 46 | 33 | 71.7 | 499 | 10.8 | 3 | 2 | 175.68 | 15.3 | 166.3 |
| 10 | Hudson Card | Texas | FR | QB | 3 | 39 | 24 | 61.5 | 314 | 8.1 | 2 | 0 | 146.09 | 13.0 | 104.7 |
| 11 | Caleb Williams | Oklahoma | FR | QB | 3 | 37 | 26 | 70.3 | 326 | 8.8 | 3 | 0 | 171.04 | 12.3 | 108.7 |
| 12 | Casey Thompson | Texas | JR | QB | 3 | 31 | 24 | 77.4 | 262 | 8.5 | 3 | 1 | 173.90 | 10.3 | 87.3 |
| 13 | Will Howard | Kansas St | SO | QB | 3 | 27 | 15 | 55.6 | 199 | 7.4 | 1 | 1 | 122.28 | 9.0 | 66.3 |
| 14 | Garrett Greene | WVU | FR | QB | 3 | 8 | 4 | 50.0 | 57 | 7.1 | 0 | 0 | 109.85 | 2.7 | 19.0 |
| 15 | Mario Williams | Oklahoma | FR | WR | 4 | 1 | 1 | 100.0 | 10 | 10.0 | 0 | 0 | 184.00 | 0.3 | 2.5 |
Note: To qualify, player must have played in 75% of his team's games.