2021 Big 12 Conference Leaders Passing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Sanders | Okla St | JR | QB | 4 | 150 | 97 | 64.7 | 1024 | 6.8 | 6 | 9 | 123.22 | 37.5 | 256.0 |
| 2 | Brock Purdy | Iowa State | SR | QB | 5 | 173 | 115 | 66.5 | 1193 | 6.9 | 5 | 6 | 127.00 | 34.6 | 238.6 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 3 | 84 | 50 | 59.5 | 636 | 7.6 | 6 | 2 | 141.93 | 28.0 | 212.0 |
| 4 | Jarret Doege | WVU | SR | QB | 3 | 82 | 55 | 67.1 | 506 | 6.2 | 1 | 3 | 115.62 | 27.3 | 168.7 |
| 5 | Donovan Smith | Texas Tech | FR | QB | 3 | 75 | 42 | 56.0 | 544 | 7.3 | 3 | 1 | 127.46 | 25.0 | 181.3 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 4 | 94 | 50 | 53.2 | 561 | 6.0 | 3 | 3 | 107.47 | 23.5 | 140.3 |
| 7 | Casey Thompson | Texas | JR | QB | 5 | 112 | 67 | 59.8 | 945 | 8.4 | 9 | 3 | 151.86 | 22.4 | 189.0 |
| 8 | Jason Bean | Kansas | JR | QB | 3 | 50 | 28 | 56.0 | 313 | 6.3 | 2 | 2 | 113.78 | 16.7 | 104.3 |
| 9 | Garrett Greene | WVU | FR | QB | 3 | 12 | 8 | 66.7 | 61 | 5.1 | 0 | 0 | 109.37 | 4.0 | 20.3 |
| 10 | Taye Barber | TCU | SR | WR | 3 | 1 | 1 | 100.0 | 7 | 7.0 | 0 | 0 | 158.80 | 0.3 | 2.3 |
| 10 | Brennan Presley | Okla St | SO | WR | 4 | 1 | 1 | 100.0 | 6 | 6.0 | 0 | 0 | 150.40 | 0.3 | 1.5 |
Note: To qualify, player must have played in 75% of his team's games.