2021 Big 12 Conference Leaders Passing - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brock Purdy | Iowa State | SR | QB | 1 | 24 | 21 | 87.5 | 288 | 12.0 | 3 | 0 | 229.55 | 24.0 | 288.0 |
| 2 | Tyler Shough | Texas Tech | JR | QB | 2 | 59 | 43 | 72.9 | 630 | 10.7 | 5 | 0 | 190.55 | 29.5 | 315.0 |
| 3 | Max Duggan | TCU | JR | QB | 1 | 28 | 16 | 57.1 | 276 | 9.9 | 3 | 0 | 175.30 | 28.0 | 276.0 |
| 4 | Spencer Rattler | Oklahoma | SO | QB | 1 | 39 | 30 | 76.9 | 304 | 7.8 | 1 | 2 | 140.60 | 39.0 | 304.0 |
| 5 | Spencer Sanders | Okla St | JR | QB | 3 | 90 | 55 | 61.1 | 618 | 6.9 | 6 | 1 | 138.57 | 30.0 | 206.0 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 2 | 52 | 33 | 63.5 | 379 | 7.3 | 1 | 1 | 127.18 | 26.0 | 189.5 |
| 7 | Jason Bean | Kansas | JR | QB | 1 | 24 | 12 | 50.0 | 189 | 7.9 | 0 | 0 | 116.15 | 24.0 | 189.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.