2021 Big 12 Conference Leaders Passing - Games on the Road/Neutral Site Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Sanders | Okla St | JR | QB | 7 | 235 | 145 | 61.7 | 1526 | 6.5 | 11 | 6 | 126.59 | 33.6 | 218.0 |
| 2 | Brock Purdy | Iowa State | SR | QB | 7 | 231 | 166 | 71.9 | 1785 | 7.7 | 11 | 5 | 148.15 | 33.0 | 255.0 |
| 3 | Jarret Doege | WVU | SR | QB | 7 | 225 | 146 | 64.9 | 1509 | 6.7 | 7 | 8 | 124.39 | 32.1 | 215.6 |
| 4 | Caleb Williams | Oklahoma | FR | QB | 6 | 130 | 82 | 63.1 | 1044 | 8.0 | 10 | 3 | 151.30 | 21.7 | 174.0 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 6 | 126 | 77 | 61.1 | 920 | 7.3 | 7 | 3 | 136.02 | 21.0 | 153.3 |
| 6 | Casey Thompson | Texas | JR | QB | 6 | 122 | 66 | 54.1 | 898 | 7.4 | 8 | 3 | 132.65 | 20.3 | 149.7 |
| 7 | Max Duggan | TCU | JR | QB | 4 | 79 | 52 | 65.8 | 739 | 9.4 | 7 | 1 | 171.10 | 19.8 | 184.8 |
| 8 | Jason Bean | Kansas | JR | QB | 5 | 86 | 44 | 51.2 | 642 | 7.5 | 2 | 5 | 109.92 | 17.2 | 128.4 |
| 9 | Donovan Smith | Texas Tech | FR | QB | 6 | 79 | 52 | 65.8 | 783 | 9.9 | 4 | 1 | 163.25 | 13.2 | 130.5 |
| 10 | Brennan Presley | Okla St | SO | WR | 7 | 2 | 1 | 50.0 | 6 | 3.0 | 0 | 0 | 75.20 | 0.3 | 0.9 |
| 11 | Trevor Wilson | Kansas | SO | WR | 6 | 1 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0.00 | 0.2 | 0.0 |
| 11 | Taye Barber | TCU | SR | WR | 5 | 1 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0.00 | 0.2 | 0.0 |
| 13 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 7 | 1 | 0 | 0.0 | 0 | 0.0 | 0 | 1 | -200.00 | 0.1 | 0.0 |
Note: To qualify, player must have played in 75% of his team's games.